• Felix L, Ziemens D, Seifert G, Rose CR.: Spontaneous Ultraslow Na + Fluctuations in the Neonatal Mouse Brain. Cells, 2019 Dec 31; 9(1). pii: E102. doi: 10.3390/cells9010102.
  • Lerchundi R, Kafitz KW, Färfers M, Beyer F, Huang N, Rose CR.: Imaging of Intracellular ATP in Organotypic Tissue Slices of the Mouse Brain Using the FRET-based Sensor ATeam1.03YEMK. J Vis Exp, 2019 Dec 19; (154). doi: 10.3791/60294.
  • Rose CR, Ziemens D, Verkhratsky A.: On the Special Role of NCX in Astrocytes: Translating Na +-transients Into Intracellular Ca 2+ Signals. Cell Calcium, 2019 Dec 23; 86:102154. doi: 10.1016/j.ceca.2019.102154. [Epub ahead of print]
  • Verkhratsky A, Rose CR.: Na+-dependent transporters: The backbone of astroglial homeostatic function. Cell Calcium, 2020 Jan; 85:102136. doi: 10.1016/j.ceca.2019.102136. Epub 2019 Dec 3.
  • Ali AAH, Schwarz-Herzke B, Rollenhagen A, Anstötz M, Holub M, Lübke J, Rose CR, Schnittler HJ, von Gall C.: Bmal1-deficiency affects glial synaptic coverage of the hippocampal mossy fiber synapse and the actin cytoskeleton in astrocytes. Glia, 2019 Nov 19; doi: 10.1002/glia.23754. [Epub ahead of print]
  • Meyer J, Untiet V, Fahlke C, Gensch T, Rose CR.: Quantitative determination of cellular [Na+] by fluorescence lifetime imaging with CoroNaGreen. J Gen Physiol, 2019 Nov 4; 151(11):1319-1331. doi: 10.1085/jgp.201912404. Epub 2019 Oct 9.
  • Gerkau NJ, Lerchundi R, Nelson JSE, Lantermann M, Meyer J, Hirrlinger J, Rose CR.: Relation between activity-induced intracellular sodium transients and ATP dynamics in mouse hippocampal neurons. J Physiol, 2019 Dec; 597(23):5687-5705. doi: 10.1113/JP278658. Epub 2019 Oct 30.
  • Ziemens D, Oschmann F, Gerkau NJ, Rose CR.: Heterogeneity of Activity-Induced Sodium Transients between Astrocytes of the Mouse Hippocampus and Neocortex: Mechanisms and Consequences. J Neurosci, 2019 Apr 3; 39(14):2620-2634. doi: 10.1523/JNEUROSCI.2029-18.2019. Epub 2019 Feb 8.
  • Verkhratsky A, Untiet V, Rose CR.: Ionic signalling in astroglia beyond calcium. J Physiol, 2019 Feb 7; doi: 10.1113/JP277478. [Epub ahead of print]
  • Gerkau NJ, Kafitz KW, Rose CR.: Imaging of Local and Global Sodium Signals in Astrocytes. Methods Mol Biol, 2019; 1938:187-202. doi: 10.1007/978-1-4939-9068-9_13.
  • Ziemens D, Oschmann F, Gerkau NJ, Rose CR. (2019): Heterogeneity of activity-induced sodium transients between astrocytes of the mouse hippocampus and neocortex: Mechanisms and consequences. J Neurosci, pii: 2029-18. doi: 10.1523/JNEUROSCI.2029-18.2019.
  • Verkhrastky A, Untiet V, Rose CR. (2019): Ionic signalling in astroglia beyond calcium. J Physiol, doi: 10.1113/JP277478.
  • Gerkau NJ, Kafitz KW, Rose CR (2019): Imaging of Local and Global Sodium Signals in Astrocytes. Methods Mol Biol, 1938:187-202. doi: 10.1007/978-1-4939-9068-9_13.
  • Lerchundi R, Kafitz KW, Winkler U, Färfers M, Hirrlinger J, Rose CR. (2018): FRET-based imaging of intracellular ATP in organotypic brain slices. J Neurosci Res, 2019 Aug; 97(8):933-945. doi: 10.1002/jnr.24361. Epub 2018 Dec 1.
  • Wadle SL, Augustin V, Langer J, Jabs R, Philippot C, Weingarten DJ, Rose CR, Steinhäuser C & Stephan J (2018): Anisotropic panglial coupling reflects tonotopic organization in the inferior colliculus. Front Cell Neurosci, 2018 Nov 27;12:431. doi: 10.3389/fncel.2018.00431. eCollection 2018.
  • Moshrefi-Ravasdjani B, Ziemens D, Pape N, Färfers M, Rose CR (2018). Action potential firing induces sodium transients in macroglial cells of the mouse corpus callosum. Neuroglia, 1 (9). doi:10.3390/neuroglia1010009.
  • Steffensen AB, Oernbo EK, Stoica A, Gerkau NJ, Barbuskaite D, Tritsaris K, Rose CR, MacAulay N (2018): Cotransporter-mediated water transport underlying cerebrospinal fluid formation. Nat Commun; 9(1):2167. doi: 10.1038/s41467-018-04677-9.
  • Petrik D, Myoga MH, Grade S, Gerkau NJ, Pusch M, Rose CR, Grothe B, Götz M (2018): Epithelial Sodium Channel Regulates Adult Neural Stem Cell Proliferation in a Flow-Dependent Manner. Cell Stem Cell, 22(6):865-878.e8. doi: 10.1016/j.stem.2018.04.016.
  • Rose CR, Felix L, Zeug A, Dietrich D, Reiner A, Henneberger C (2018): Astroglial Glutamate Signaling and Uptake in the Hippocampus. Front Mol Neurosci, 10:451. doi: 10.3389/fnmol.2017.00451.
  • Gerkau NJ, Rakers C, Durry S, Petzold GC, Rose CR (2018): Reverse NCX Attenuates Cellular Sodium Loading in Metabolically Compromised Cortex. Cereb Cortex, 28(12):4264-4280. doi: 10.1093/cercor/bhx280.
  • Karus K, Gerkau NJ, Rose CR (2017): Differential Contribution of GLAST and GLT-1 to Network Sodium Signaling in the Early Postnatal Hippocampus. Opera Med Physiol, 3 (3-4): 71-83.
  • Hesse J, Leberling S, Boden E, Friebe D, Schmidt T, Ding Z, Dieterich P, Deussen A, Roderigo C, Rose CR, Floss DM, Scheller J, Schrader J (2017): CD73-derived adenosine and tenascin-C control cytokine production by epicardium-derived cells formed after myocardial infarction. FASEB J, 31(7):3040-3053.
  • Ona-Jodar T, Gerkau NJ, Sara Aghvami S, Rose CR, Egger V (2017): Two-Photon Na+ Imaging Reports Somatically Evoked Action Potentials in Rat Olfactory Bulb Mitral and Granule Cell Neurites. Front Cell Neurosci, 28;11:50.
  • Moshrefi-Ravasdjani B, Hammel EL, Kafitz KW, Rose CR (2017): Astrocyte Sodium Signalling and Panglial Spread of Sodium Signals in Brain White Matter. Neurochem Res, 42(9):2505-2518.
  • Gerkau NJ, Rakers C, Petzold GC, Rose CR (2017): Differential effects of energy deprivation on intracellular sodium homeostasis in neurons and astrocytes. J Neurosci Res, 95(11):2275-2285
  • Untiet V, Kovermann P, Gerkau NJ, Gensch T, Rose CR, Fahlke C. (2017): Glutamate transporter-associated anion channels adjust intracellular chloride concentrations during glial maturation. Glia, 65(2):388-400.
  • Langer J, Gerkau NJ, Derouiche A, Kleinhans C, Moshrefi-Ravasdjani B, Fredrich M, Kafitz KW, Seifert G, Steinhäuser C, Rose CR. (2017): Rapid sodium signaling couples glutamate uptake to breakdown of ATP in perivascular astrocyte endfeet. Glia, 65(2):293-308.
  • Rose CR, Ziemens D, Untiet V, Fahlke C. (2016): Molecular and cellular physiology of sodium-dependent glutamate transporters. Brain Res Bull, 28. pii: S0361-9230(16)30482-8.
  • Rose CR, Verkhratsky A. (2016):Glial ionic excitability: The role for sodium. Glia, 64(10):1609-10.
  • Augustin V, Bold C, Wadle SL, Langer J, Jabs R, Philippot C, Weingarten DJ, Rose CR, Steinhäuser C, Stephan J (2016): Functional anisotropic panglial networks in the lateral superior olive. Glia, 64(11):1892-911.
  • Moshrefi-Ravasdjani B, Dublin P, Seifert G, Jennissen K, Steinhäuser C, Kafitz KW, Rose CR (2017): Changes in the proliferative capacity of NG2 cell subpopulations during postnatal development of the mouse hippocampus. Brain Struct Funct, 222(2):831-847
  • Mondragão MA, Schmidt H, Kleinhans C, Langer J, Kafitz KW, Rose CR (2016): Extrusion versus diffusion: mechanisms for recovery from sodium loads in mouse CA1 pyramidal neurons. J Physiol, 1;594(19):5507-27.
  • Rose CR, Verkhratsky A (2016): Principles of sodium homeostasis and sodium signalling in astroglia. Glia, 64(10):1611-27.
  • Karus C, Ziemens D, Rose CR (2015): Lactate rescues neuronal sodium homeostasis during impaired energy metabolism. Channels (Austin), 4;9(4):200-8.
  • Rose CR, Chatton JY (2015): Astrocyte sodium signaling and neuro-metabolic coupling in the brain. Neuroscience, 16. pii: S0306-4522(15)00213-4.
  • Karus C, Mondragão MA, Ziemens D, Rose CR (2015): Astrocytes restrict discharge duration and neuronal sodium loads during recurrent network activity. Glia, 63(6):936-57.
  • Hertz L, Gerkau NJ, Xu J, Durry S, Song D, Rose CR, Peng L (2015): Roles of astrocytic Na+, K+ -ATPase and glycogenolysis for K+ homeostasis in mammalian brain. J Neurosci Res, 93(7):1019-30.
  • Kleinhans C, Kafitz KW, Rose CR (2014): Multi-photon intracellular sodium imaging combined with UV-mediated focal uncaging of glutamate in CA1 pyramidal neurons. J Vis Exp, 8;(92):e52038.
  • Haack N, Dublin P, Rose CR (2014): Dysbalance of Astrocyte Calcium under Hyperammonemic Conditions. PLoS One, 25;9(8):e105832.
  • Gassmann K, Schreiber T, Dingemans MM, Krause G, Roderigo C, Giersiefer S, Schuwald J, Moors M, Unfried K, Bergman Å, Westerink RH, Rose CR, Fritsche E (2014): BDE-47 and 6-OH-BDE-47 modulate calcium homeostasis in primary fetal human neural progenitor cells via ryanodine receptor-independent mechanisms. Arch Toxicol, 88(8):1537-48.
  • Haack N, Rose CR (2014): Preparation, Calibration and Application of Potassium-Selective Microelectrodes. In: Microelectrodes: Techniques, Structures for Biosensing and Potential Applications. Ed: Lei KF, Nova Science Publishers.
  • Schreiner AE, Durry S, Aida T, Stock MC, Rüther U, Tanaka K, Rose CR, Kafitz KW (2014): Laminar and subcellular heterogeneity of GLAST and GLT-1 immunoreactivity in the developing postnatal mouse hippocampus. J Comp Neurol, doi: 10.1002/cne.23450
  • Schreiner AE, Berlinger E, Langer J, Kafitz KW, Rose CR (2013): Lesion-Induced Alterations in Astrocyte Glutamate Transporter Expression and Function in the Hippocampus. ISRN Neurology Volume 2013.
  • Schreiner AE, Rose CR (2013): Quantitative imaging of intracellular sodium. In: Current microscopy contributions to advances in science and technology. Mendez-Vilas A. (ed), Formatex Research Centre, Badajoz, Spain.
  • Rose CR, Karus C (2013): Two sides of the same coin: Sodium homeostasis and signaling in astrocytes under physiological and pathophysiological conditions. Glia, 61(8):1191-205.
  • Rose CR (2012): Two-photon sodium imaging in dendritic spines. Cold Spring Harb Protoc, doi: 10.1101/pdb.prot072074.
  • Stephan J, Haack N, Kafitz KW, Durry S, Koch D, Hochstrate P, Seifert G, Steinhäuser C, Rose CR (2012): Kir4.1 channels mediate a depolarization of hippocampal astrocytes under hyperammonemic conditions in situ. Glia, 60(6):965-78
  • Goedecke S, Roderigo C, Rose CR, Rauch BH, Goedecke A, Schrader J. (2012): Thrombin-induced ATP release from human umbilical vein endothelial cells. Am J Physiol Cell Physiol, 302:C915-23
  • Langer J, Stephan J, Theis M, Rose CR (2012): Gap junctions mediate intercellular spread of sodium between hippocampal astrocytes in situ. Glia, 60(2):239-52.
  • Stettner M, Dehmel T, Mausberg AK, Köhne A, Rose CR, Kieseier BC (2011): Levetiracetam exhibits protective properties on rat Schwann cells in vitro. Journal of the Peripheral Nervous System, 16:250–260
  • Scherbart AM, Langer J, Bushmelev A, van Berlo D, Haberzettl P, van Schooten FJ, Schmidt AM, Rose CR, Schins RP, Albrecht C (2011): Contrasting macrophage activation by fine and ultrafine titanium dioxide particles is associated with different uptake mechanisms. Part Fibre Toxicol, 13;8:31.
  • Walter J, Honsek SD, Illes S, Wellen J, Hartung H-P, Rose CR, Dinhe M (2011): A new role for interferon gamma in neural stem/precursor cell dysregulation. Molec Neurodegen, 3;6:18.
  • Kelly T, Rose CR (2010): Ammonium influx pathways into neurones and astrocytes of hippocampal slices. J Neurochemistry, 115(5):1123-36.
  • Honsek SD, Walz C, Kafitz KW, Rose CR (2010): Astrocyte calcium signals at Schaffer collateral to CA1 pyramidal cell synapses correlate with the number of activated synapses but not with synaptic strength. Hippocampus, 22(1):29-42.
  • Schreiber T, Gassmann K, Moors M, Krause G, Merk HF, Nguyen N-H, Scanlan TS, Abel J, Rose CR, Fritsche E (2010): Polybrominated Diphenyl Ethers induce developmental neurotoxicity in a human in vitro model: evidence for endocrine disruption. Environmental Health Perspectives, 118(4):572-8.
  • Kelly, T, & Rose C.R. (2010): Intra- und extrazelluläre Ionenverschiebungen bei hepatischer Enzephalopathie und ihre funktionellen Folgen. Invited Review. Neuroforum (Organ der Neurowiss. Gesellschaft): Volume 02/2010
  • Langer J, Rose CR (2010): Synaptically-induced sodium signals in hippocampal astrocytes in situ. J Physiol, 587:5859-5877.
  • Kelly T & Rose CR: Sodium signals in axons. Invited Review. In: Axons: Advances in Morphology, Physiology, Development, Computation and Pathophysiology, D. Feldmeyer and J. Lübke, eds. (Springer Verlag)
  • Deitmer JW, Rose CR (2010): Ion changes and signalling in perisynaptic glia. Brain Res Reviews, in press. 
  • Filosa A, Paixao S, Honsek SD, Carmona M, Becker L, Feddersen B, Gaitanos L, Rudhard Y, Schoepfer R, Klopstock T, Kullander K, Rose CR, Pasquale EB, Klein R (2009): Neuron-glia communication via EphA4/ephrinA3 modulates glial glutamate transporter levels and synaptic plasticity. Nature Neurosci, 12: 1285-1292.
  • Kelly T, Kafitz KW, Roderigo C & Rose CR (2008): Ammonium-evoked alterations in intracellular sodium and pH reduce glial glutamate transport activity. Glia, 57: 921-934.
  • Meier SD, Kafitz KW, Rose CR (2008): Developmental profile and mechanisms of GABA-induced calcium signaling in hippocampal astrocytes. Glia, 56:1127-37.
  • Bennay M, Langer J, Meier SD, Kafitz KW, Rose CR (2008): Sodium signals in cerebellar Purkinje neurons and Bergmann glial cells evoked by glutamatergic synaptic transmission. Glia, 56:1138-49
  • Kafitz KW, Meier SD, Stephan J & Rose CR (2008): Developmental profile and properties of sulforhodamine (SR101)-positive astrocytes in acute brain slices of rat hippocampus. J Neurosci Methods 169: 84-92.
  • Meier SD, Kovalchuk Y & Rose CR (2006): Properties of the new fluorescent Na+ indicator CoroNa Green: Comparison with SBFI and confocal Na+ Imaging. J Neurosci Methods 155, 251-259.
  • Rose CR (2005): Two-photon Na+ imaging. In: Imaging in Neuroscience and Development: A Laboratory Manual. R. Yuste, F. Lanni und A. Konnerth (Hrsg.) CSH Laboratory Press, Cold Spring Harbor.
  • Rose CR, Blum R, Kafitz KW & Konnerth A (2004): From modulators to mediators: Rapid effects of neurotrophins on ion channels. Bioessays 26:1185-1194. 
  • Rose CR (2003): High resolution Na+ imaging. Pflügers Arch (Eur J Physiol) 446:317-321.
  • Rose CR, Konnerth A & Becker C-M (2003): Synapsen. In: Lehrbuch der Vorklinik, Schmidt RF & Unsicker K (eds), Deutscher Ärzte-Verlag.
  • Rose CR, Blum R, Pichler B, Lepier A, Kafitz KW, & Konnerth A (2003): Glia-specific neurotrophin-evoked calcium signalling through truncated TrkB-T1 receptors. Nature, 426:74-78. 
  • Barski JJ, Hartmann J, Rose CR, Hoebeek F, Mörl, K, Noll-Hussong M, De Zeeuw CI, Konnerth A & Meyer M (2003): Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination. J Neurosci 23: 3469-3477.
  • Shakhman O, Herkert M, Rose CR, Humeny A & Becker C-M (2003): Induction by ß-bungarotoxin of apoptosis in cultured hippocampal neurons is mediated by Ca2+-dependent formation of reactive oxygen species. J Neurochem, 87: 598-608.
  • Feil R, Gappa N, Rutz M, Schlossmann J, Rose CR, Konnerth A, Brummer S, Kühbandner S & Hofmann F (2002): Functional reconstitution of vascular smooth muscle cells with cGMP-dependent protein kinase I isoforms. Circulation Res 90: 1080-1086.
  • Rose CR (2002): Na+ signals at central synapses. The Neuroscientist 8: 532-539.
  • Rose CR & Konnerth A (2001): NMDA receptor-mediated Na+ signals in spines and dendrites. J Neurosci 27: 4207-4214. 
  • Rose CR & Konnerth A (2001): Stores not just for storage: Intracellular calcium release and synaptic plasticity. Neuron 31: 519-522.
  • Rose CR & Konnerth A (2001): Exciting glial oscillations. Nature Neuroscience 4: 773-774.
  • Rose CR & Konnerth A (2001): Netzwerke und Schaltkreise oder: Eine Nervenzelle macht noch kein Gehirn. In: Kosmos Gehirn. H. Kettenmann and M. Gibson (eds), Neurowissenschaftliche Gesellschaft e. V., Berlin, pp. 24-25.
  • Kafitz KW, Rose CR & Konnerth A (2000): Neurotrophin-evoked rapid excitation of central neurons. Prog Brain Res 128: 243-249.
  • Rose CR & Konnerth A (2000): Self-regulating synapses. Nature 6785: 413-415.
  • Deitmer JW, Rose CR, Munsch T, Schmidt J, Nett, W, Schneider H-P & Lohr C (1999): Leech giant glial cell: Functional role in a simple nervous system. Glia, 28: 175-182.
  • Rose CR, Kovalchuk Y, Eilers J & Konnerth A (1999): Two-photon Na+ imaging in spines and fine dendrites of central neurons. Pflügers Arch 439: 201-207.
  • Kafitz KW, Rose CR, Thoenen H & Konnerth A (1999): Neurotrophin-evoked rapid excitation through TrkB receptors. Nature 401: 918-921.      
  • Longuemare MC, Rose CR, Ransom BR, Waxman SG & Swanson RA (1999): K+-induced reversal of astrocyte glutamate uptake is limited by compensatory changes in intracellular Na+. Neuroscience 93: 285-292.
  • Rose CR, Ransom BR & Waxman SG (1998): Effects of glucose deprivation, chemical hypoxia, and simulated ischemia on Na+ homeostasis in rat spinal cord astrocytes. J Neurosci 18: 3554-3562.
  • Rose CR & Ransom BR (1998): pH regulation in mammalian glia. In: pH and Brain Function. K. Kaila und B. R. Ransom (Hrsg.), Wiley, New York, pp. 247-269.
  • Rose CR & Ransom BR (1997): Regulation of intracellular sodium in cultured rat hippocampal neurones. J Physiol (Lond) 499: 573-587.
  • Rose CR & Ransom BR (1997): Gap junctions equalize intracellular Na+ concentration in astrocytes. Glia 20: 299-307.
  • Rose CR, Ransom BR & Waxman SG (1997): Pharmacological characterization of Na+ influx via voltage-gated Na+ channels in spinal cord astrocytes. J Neurophysiol 78: 3249-3258.
  • Rose CR (1997): Intracellular Na+ regulation in neurons and glia: Functional implications. The Neuroscientist 3:  85-88.
  • Rose CR & Ransom BR (1996): Intracellular sodium homeostasis in rat hippocampal astrocytes. J Physiol (Lond) 491: 291-305.
  • Rose CR & Ransom BR (1996): Mechanisms of H+ and Na+ changes induced by glutamate, kainate, and D-aspartate in rat hippocampal astrocytes. J Neurosci 16: 5393-5404.
  • Lohr C, Rose CR & Deitmer JW (1996): Extracellular Ca2+ changes during transmitter application in the leech CNS. Neurosci Letters 205: 1-4.
  • Deitmer JW & Rose CR (1996): pH regulation and proton signalling by glial cells. Prog Neurobiol 48: 73-103.
  • Rose CR, Lohr C & Deitmer JW (1995): Activity-induced Ca2+ transients in nerve and glial cells in the leech CNS. NeuroReport 6: 642-644.
  • Rose CR & Deitmer JW (1995): Stimulus-evoked changes in extra- and intracellular pH in the leech central nervous system. II. Mechanisms and maintenance of pH homeostasis. J Neurophysiol 73:132-140.
  • Rose CR & Deitmer JW (1995): Stimulus-evoked changes in extra- and intracellular pH in the leech central nervous system. I. Bicarbonate dependence. J Neurophysiol 73: 125-131.
  • Rose CR & Deitmer JW (1994): Evidence that glial cells modulate extracellular pH transients induced by neuronal activity in the leech central nervous system. J Physiol (Lond) 481: 1-5


Prof. Dr. Christine R. Rose

Institut fuer Neurobiologie
Universitaetsstraße 1
Gebäude: 26.02
Etage/Raum: 00.35
40225 Duesseldorf
Tel.: +49 211 81-13416


Tanja König

Gebäude: 26.02
Etage/Raum: 00.31
Tel.: +49 211 81-13414


Dr. Wolfgang Karl Kafitz

Tel.: +49 211 81-13486
Verantwortlich für den Inhalt: E-Mail sendenProf. Dr. Christine Rose